The effects of hypertension and sleep disorders on risk of dementia

 
   Lead Investigator:    Cheryl Lim
   Institution      :    Nanyang Technological University
   E-Mail           :    CLIM096@e.ntu.edu.sg
   Proposal ID      :    1522



   Proposal Description:
   Hypertension and sleep disorders such as sleep apnea have been previously shown  to be associated with an increased risk for dementia. However, the interactive   and mediating effects of these two variables in combination on cognitive         decline and progression to dementia have not been examined. Here we aim to       investigate 1) whether the relationship between hypertension and longitudinal     cognitive decline is moderated or mediated by the presence of sleep disorders     and 2) whether the use of antihypertensives moderates the relationship between   hypertension and sleep disorders on longitudinal cognitive decline and           progression to dementia.